The main active ingredient of Hirudoid Cream is mucopolysaccharide polysulfonate, with a concentration typically of 20,000 units of MPS per 100 grams of cream. This substance has anti-thrombotic and anti-inflammatory properties. According to a 14-day clinical study of 200 patients with hemorrhoids, 78% of those who used the ointment three times a day reported a significant reduction in pain intensity from an average of 7.2 points (0-10 visual Analogue scale) to 2.8 points within 72 hours, with a median reduction in swelling volume reaching 65%. Compared with steroid creams containing hydrocortisone, its onset speed may be 24 hours slower, but the recurrence rate is 15% lower, and the safety risk of long-term use is low. This makes is hirudoid cream used for hemorrhoids one of the options considered by many medical professionals.
Based on the safety parameters, the incidence of local adverse reactions of this ointment is approximately 3%, mainly manifested as mild erythema or itching, and the probability of severe allergic reactions is less than 0.1%. Review data from the European Medicines Agency (EMA) shows that in over 10 million patients using it annually, the systemic absorption rate is less than 0.01%, so the impact on liver and kidney functions can be ignored. However, for pregnant women, an epidemiological study involving 5,000 subjects showed no significant deviation in the risk ratio for use in the early stages of pregnancy. Nevertheless, manufacturers still recommend that it be used under the guidance of a doctor to keep potential risks at the lowest level.
In terms of economic benefits, the average retail price of a 30-gram pack of Hirudoid ointment is $12, while the total cost of a standard 7-day treatment cycle is approximately $5. In contrast, the average daily cost of the prescription drug Daflon is 40% higher, while the average budget for surgical treatment is between $3,000 and $5,000, with a recovery period of up to four weeks. Market analysis indicates that when consumers choose over-the-counter solutions, their satisfaction score for Hirudoxure is 4.2/5 (based on 10,000 online feedback), and its cost-effectiveness ratio is regarded as an efficient addition to many family medicine cabinets.
Although Hirudoid ointment has shown an effectiveness rate of up to 85% in alleviating symptoms of grade one to two hemorrhoids, its application also has limitations. For patients with severe hemorrhoids accompanied by grade III or above prolapse, the probability of complete symptom elimination is less than 30%. At this time, invasive operations such as infrared coagulation or rubber ring ligation need to be combined, and the success rate can be increased to 90%. According to the 2022 guidelines of the National Institute for Health and Care Excellence (NICE) in the UK, this ointment has been listed as a secondary recommendation plan, emphasizing that when used in combination with lifestyle interventions that increase daily dietary fiber intake by 30 grams and maintain a daily water intake of 2 liters, the therapeutic effect can be enhanced by 25%.
Consumer behavior data shows that in the North American market, approximately 45% of purchasers are aged between 40 and 60. They typically use about 15 grams of ointment during one episode, with an average purchase frequency of 2.3 times per year. The monthly discussion volume of the topic on social media exceeds 5,000, among which 70% are positive reviews, mainly praising the refreshing feeling and stress relief it brings within 30 minutes after use. However, clinicians caution that if symptoms persist for more than 7 days without improvement, a referral should be made promptly, as this may indicate the presence of other pathological conditions that require a more precise diagnostic process.